Graphene oxide stabilized by PLA-PEG copolymers for the controlled delivery of paclitaxel.

@article{Angelopoulou2015GrapheneOS,
  title={Graphene oxide stabilized by PLA-PEG copolymers for the controlled delivery of paclitaxel.},
  author={Athina Angelopoulou and Evangelia Voulgari and Evmorfia K Diamanti and Dimitrios Gournis and Konstantinos Avgoustakis},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2015},
  volume={93},
  pages={18-26}
}
PURPOSE To investigate the application of water-dispersible poly(lactide)-poly(ethylene glycol) (PLA-PEG) copolymers for the stabilization of graphene oxide (GO) aqueous dispersions and the feasibility of using the PLA-PEG stabilized GO as a delivery system for the potent anticancer agent paclitaxel. METHODS A modified Staudenmaier method was applied to synthesize graphene oxide (GO). Diblock PLA-PEG copolymers were synthesized by ring-opening polymerization of dl-lactide in the presence of… CONTINUE READING