Graph models of oncogenesis with an application to melanoma.

  title={Graph models of oncogenesis with an application to melanoma.},
  author={Michael D. Radmacher and Richard Simon and Richard Desper and Raymond M Taetle and Alejandro A. Sch{\"a}ffer and Michelle A Nelson},
  journal={Journal of theoretical biology},
  volume={212 4},
We describe several analytical techniques for use in developing genetic models of oncogenesis including: methods for the selection of important genetic events, construction of graph models (including distance-based trees, branching trees, contingency trees and directed acyclic graph models) from these events and methods for interpretation of the resulting models. The models can be used to make predictions about: which genetic events tend to occur early, which events tend to occur together and… CONTINUE READING
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