Graph-based data integration predicts long-range regulatory interactions across the human genome

@article{Demeyer2014GraphbasedDI,
  title={Graph-based data integration predicts long-range regulatory interactions across the human genome},
  author={S. Demeyer and T. Michoel},
  journal={bioRxiv},
  year={2014}
}
  • S. Demeyer, T. Michoel
  • Published 2014
  • Biology
  • bioRxiv
  • Transcriptional regulation of gene expression is one of the main processes that affect cell diversification from a single set of genes. Regulatory proteins often interact with DNA regions located distally from the transcription start sites (TSS) of the genes. We developed a computational method that combines open chromatin and gene expression information for a large number of cell types to identify these distal regulatory elements. Our method builds correlation graphs for publicly available… CONTINUE READING

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