Graph Theoretical Insights into Evolution of Multidomain Proteins

  title={Graph Theoretical Insights into Evolution of Multidomain Proteins},
  author={Teresa M. Przytycka and George B. Davis and Nan Song and Dannie Durand},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={13 2},
We study properties of multidomain proteins from a graph theoretical perspective. In particular, we demonstrate connections between properties of the domain overlap graph and certain variants of Dollo parsimony models. We apply our graph theoretical results to address several interrelated questions: do proteins acquire new domains infrequently, or often enough that the same combinations of domains will be created repeatedly through independent events? Once domain architectures are created do… CONTINUE READING
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