Grapefruit juice substantially increases plasma concentrations of buspirone

@article{Lilja1998GrapefruitJS,
  title={Grapefruit juice substantially increases plasma concentrations of buspirone},
  author={Jari J. Lilja and Kari T. Kivistö and Janne T. Backman and Tommi S. Lamberg and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1998},
  volume={64}
}
Buspirone has a low oral bioavailability because of extensive first‐pass metabolism. The effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of orally administered buspirone is not known. 
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References

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TLDR
This work wanted to investigate a possible interaction of grapefruit juice with lovastatin, a cholesterollowering agent that is partially metabolized by CYP3A4. Expand
Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole
TLDR
The oral bioavailability of buspirone is very low as a result of extensive first‐pass metabolism, and the possible interactions with erythromycin and itraconazole have not been studied before. Expand
Interaction between grapefruit juice and midazolam in humans
TLDR
To investigate the effects of grapefruit juice on the pharmacokinetics and dynamics of midazolam, a new grapefruit-based formulation of the drug is developed. Expand
Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone
TLDR
This study investigated possible interactions of buspirone with verapamil and diltiazem to determine its first‐pass metabolism and found it potentially susceptible to drug interactions. Expand
Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram
To establish whether the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine are affected by concomitant administration of grapefruit juice and to determine whether any effectExpand
The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients
TLDR
To estimate the effect of grapefruit juice on cyclosporine and prednisone metabolism, a large amount of data is needed to estimate the concentration of these drugs in fruit juice. Expand
Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.
TLDR
A mechanism for the effect of grapefruit juice on oral felodipine kinetics is its selective downregulation of CYP3A4 in the small intestine. Expand
Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin
TLDR
Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals. Expand
Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics
TLDR
Current information supports the cautioning of patients about concomitant ingestion of grapefruit juice and nisoldipine, and the interaction could not be predicted from baseline pharmacokinetics with water and resulted in greater interindividual variability. Expand
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TLDR
It is suggested that grapefruit juice increases trough concentrations of cyclosporine in blood, possibly by inhibiting pre-hepatic gut wall metabolism, and could be useful in optimizing therapy with this drug. Expand
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