Grapefruit juice substantially increases plasma concentrations of buspirone

  title={Grapefruit juice substantially increases plasma concentrations of buspirone},
  author={Jari J. Lilja and Kari T. Kivistö and Janne T. Backman and Tommi S. Lamberg and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},

Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol

Our objective was to evaluate the effects of itraconazole and grapefruit juice on the pharmacokinetics of the β‐adrenergic receptor‐blocking agent celiprolol in healthy volunteers.

Grapefruit juice–felodipine interaction in the elderly

Grapefruit juice can increase the oral bioavailability of a broad range of medications. This interaction has not been assessed in the elderly.

Grapefruit Juice-fluvoxamine Interaction: Is It Risky Or Not?

One of the selective serotonin reuptake inhibitors, fluvoxamine, is eliminated predominantly by oxidation through cytochrome P 450 (CYP) and it is possible that the disposition of fluv oxamine is involved in a complex metabolic pathway.

Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine

Grapefruit juice increases the bioavailability of several orally administered CYP3A4 substrates by inhibiting CYP 3A4 at the enterocyte level and could increase the risk of halofantrine‐induced QT interval prolongation.

Interaction between Grapefruit Juice and Praziquantel in Humans

The area under the concentration-time curve and the maximum concentration in plasma of praziquantel (Cmax) were significantly increased and no statistically significant differences were found in the time to maximum concentration of drug in plasma or elimination half-life.

Plasma levels of clozapine and desmethylclozapine are unaffected by concomitant ingestion of grapefruit juice

The present study was performed to investigate whether grapefruit juice in ̄uences the pharmacokinetic of clozapine.

Grapefruit juice-drug interaction issues.

Concomitant drug and food intake create the opportunity for an interaction that may change (increase or decrease) drug benefit or toxicity.

Grapefruit: the last decade acquisitions.

Interactions between grapefruit juice and some drugs available in Australia

This booklet contains information on how to identify the different types of cannabinoids in the blood stream and how to select the good for humans and animals.



Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

A mechanism for the effect of grapefruit juice on oral felodipine kinetics is its selective downregulation of CYP3A4 in the small intestine.

Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin

Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals.

Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

Current information supports the cautioning of patients about concomitant ingestion of grapefruit juice and nisoldipine, and the interaction could not be predicted from baseline pharmacokinetics with water and resulted in greater interindividual variability.

Trough concentrations of cyclosporine in blood following administration with grapefruit juice.

It is suggested that grapefruit juice increases trough concentrations of cyclosporine in blood, possibly by inhibiting pre-hepatic gut wall metabolism, and could be useful in optimizing therapy with this drug.