Grapefruit juice-nifedipine interaction: possible involvement of several mechanisms.

Abstract

OBJECTIVE To develop a model based on mean residence time for better understanding the effect of grapefruit juice on the metabolism of nifedipine (NIF). MATERIAL AND METHODS Sixteen healthy volunteers from an urban population were included. For each trial, the subjects drank water, fresh grapefruit juice or bottled grapefruit juice. Thirty minutes later… (More)

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Cite this paper

@article{Odou2005GrapefruitJI, title={Grapefruit juice-nifedipine interaction: possible involvement of several mechanisms.}, author={Pascal Odou and Nina Ferrari and Catherine Barth{\'e}l{\'e}my and Serge Brique and M. Lhermitte and A. Vincent and Cl. Libersa and H{\'e}l{\`e}ne Robert}, journal={Journal of clinical pharmacy and therapeutics}, year={2005}, volume={30 2}, pages={153-8} }