Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

@article{Lilja1999GrapefruitJI,
  title={Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin},
  author={Jari J. Lilja and Kari T. Kivistö and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1999},
  volume={66}
}
Grapefruit juice greatly increases the bioavailability of lovastatin and simvastatin. We studied the effect of grapefruit juice on the pharmacokinetics of atorvastatin and pravastatin. 
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GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin Acid by 13% (-3 to 29%). Expand
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Results: In the acute study, pineapple and grapefruit signifi cantly decreased plasma triacylglycerol [TAG], and chylomicron [CM] TAG and cholesterol concentrations concomitantly with delayed gastric… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid
TLDR
This work wanted to investigate a possible interaction of grapefruit juice with lovastatin, a cholesterollowering agent that is partially metabolized by CYP3A4. Expand
Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG‐CoA reductase inhibitors
TLDR
This work studied the effect of grapefruit juice on the pharmacokinetics of orally administered simvastatin and found it to be positive for cholesterol‐lowering activity. Expand
Interaction between grapefruit juice and midazolam in humans
TLDR
To investigate the effects of grapefruit juice on the pharmacokinetics and dynamics of midazolam, a new grapefruit-based formulation of the drug is developed. Expand
Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
TLDR
To examine the effect of grapefruit juice on the disposition of cyclosporine after administration of oral and intravenous doses to healthy male subjects, grapefruit Juice is used as a raw material for the drug conjugation test. Expand
Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid
TLDR
Itraconazole is a potent inhibitor of CYP3A4, and a possible interaction between these drugs was studied to study the risk of skeletal muscle toxicity following conjunction use of these drugs. Expand
Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole
Itraconazole increases the risk of skeletal muscle toxicity of some 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors by increasing their serum concentrations. We studied possible… Expand
Effect of grapefruit juice on blood cyclosporin concentration
TLDR
Grapefruit juice may provide a non-toxic and inexpensive alternative to drugs that are used to reduce cyclosporin dose. Expand
The interaction of diltiazem with lovastatin and pravastatin
TLDR
Diltiazem, a substrate and a potent inhibitor of cytochrome P4503A enzymes, is commonly coadministered with cholesterol‐lowering agents. Expand
Effect of itraconazole on the pharmacokinetics of atorvastatin
TLDR
The aim of this study was to characterize the effect of itraconazole on the pharmacokinetics of atorvastatin, a new HMG‐CoA reductase inhibitor that is metabolized at least in part by CYP3A4. Expand
Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin
TLDR
Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals. Expand
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