Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

@article{Lilja1999GrapefruitJI,
  title={Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin},
  author={Jari J. Lilja and Kari T. Kivistö and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1999},
  volume={66}
}
Grapefruit juice greatly increases the bioavailability of lovastatin and simvastatin. We studied the effect of grapefruit juice on the pharmacokinetics of atorvastatin and pravastatin. 
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GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin Acid by 13% (-3 to 29%).
Effect of acute and chronic grapefruit , orange , and pineapple juice intake on blood lipid profi le in normolipidemic rat
Results: In the acute study, pineapple and grapefruit signifi cantly decreased plasma triacylglycerol [TAG], and chylomicron [CM] TAG and cholesterol concentrations concomitantly with delayed gastric…
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Effect of multidose cilostazol on pharmacokinetic and lipid profile of atorvastatin in male Wistar rats
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The drug–drug interaction potential of multi‐dose CLZ on both pharmacokinetics and the lipid‐lowering ability of single‐dose ATV is demonstrated.
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References

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Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid
Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG‐CoA reductase inhibitors
Interaction between grapefruit juice and midazolam in humans
Disposition of intravenous and oral cyclosporine after administration with grapefruit juice
Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid
Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole
Effect of grapefruit juice on blood cyclosporin concentration
The interaction of diltiazem with lovastatin and pravastatin
Effect of itraconazole on the pharmacokinetics of atorvastatin
Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin
TLDR
Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals.
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