Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin

  title={Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin},
  author={Jari J. Lilja and Kari T. Kivistö and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
Grapefruit juice greatly increases the bioavailability of lovastatin and simvastatin. We studied the effect of grapefruit juice on the pharmacokinetics of atorvastatin and pravastatin. 
Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol
Our objective was to evaluate the effects of itraconazole and grapefruit juice on the pharmacokinetics of the β‐adrenergic receptor‐blocking agent celiprolol in healthy volunteers.
Grapefruit juice–felodipine interaction in the elderly
Grapefruit juice can increase the oral bioavailability of a broad range of medications. This interaction has not been assessed in the elderly.
Effect of grapefruit juice on digoxin pharmacokinetics in humans
Effects of Grapefruit Juice Consumption on Pharmacokinetics of Low Dose Simvastatin: Cross-over Study with a Review of the Literature
Consumption of grapefruit juice with low-dose simvastatin resulted in mild increase of the plasma HMG-CoA reductase inhibitor, so that the pharmacokinetic interaction can be labeled as of weak CYP3A type.
Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.
GFJ increased the mean AUC(0-24) of atorvastatin acid by 83% (95% CI 23-144%) and that of pitavastatin Acid by 13% (-3 to 29%).
Effect of acute and chronic grapefruit , orange , and pineapple juice intake on blood lipid profi le in normolipidemic rat
Results: In the acute study, pineapple and grapefruit signifi cantly decreased plasma triacylglycerol [TAG], and chylomicron [CM] TAG and cholesterol concentrations concomitantly with delayed gastric
Interactions between grapefruit juice and some drugs available in Australia
This booklet contains information on how to identify the different types of cannabinoids in the blood stream and how to select the good for humans and animals.
Effect of multidose cilostazol on pharmacokinetic and lipid profile of atorvastatin in male Wistar rats
The drug–drug interaction potential of multi‐dose CLZ on both pharmacokinetics and the lipid‐lowering ability of single‐dose ATV is demonstrated.


Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole
The interaction of diltiazem with lovastatin and pravastatin
Effect of itraconazole on the pharmacokinetics of atorvastatin
Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin
Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals.