Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.

@article{Gertz2008GrapefruitJI,
  title={Grapefruit juice-drug interaction studies as a method to assess the extent of intestinal availability: utility and limitations.},
  author={Michael Gertz and John R. Davis and Anthony Harrison and J. Brian Houston and Aleksandra Galetin},
  journal={Current drug metabolism},
  year={2008},
  volume={9 8},
  pages={785-95}
}
This study aims to assess utility and limitations of grapefruit juice (GFJ) interaction studies as alternative in vivo approach to estimate intestinal availability (F(G)) in comparison to the predominantly used i.v./oral method. The F(G) estimates were obtained from the ratio of AUC in the control and the GFJ group reported previously. Due to large variability in the study design, the following inclusion criteria were applied for the selection of clinical studies: no change in elimination half… CONTINUE READING
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