Corpus ID: 89485100

Grapefruit juice and saquinavir.

@article{Js1995GrapefruitJA,
  title={Grapefruit juice and saquinavir.},
  author={James Js},
  journal={AIDS treatment news},
  year={1995},
  pages={5-6}
}
  • James Js
  • Published 1995
  • Chemistry
  • AIDS treatment news
: One problem with saquinavir is that it is poorly absorbed by the body because it is rapidly destroyed by cytochrome P456 3A4, a liver enzyme found in the intestinal wall. Studies show that properties in grapefruit juice inhibit this enzyme and increase saquinavir's efficiency. Published studies show similar results with other drugs. However, grapefruit juice's effects on drug bioavailability could vary greatly from person to person, and there is no commercially available test to measure… Expand
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