Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG‐CoA reductase inhibitors

@article{Lilja1998GrapefruitJI,
  title={Grapefruit juice—simvastatin interaction: Effect on serum concentrations of simvastatin, simvastatin acid, and HMG‐CoA reductase inhibitors},
  author={J. Lilja and K. Kivistö and P. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1998},
  volume={64}
}
Simvastatin is a cholesterol‐lowering agent that is metabolized through CYP3A4. We studied the effect of grapefruit juice on the pharmacokinetics of orally administered simvastatin. 
Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin
The interaction of diltiazem with simvastatin
Grapefruit juice–felodipine interaction in the elderly
Processing grapefruit juice with γ‐cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity
Grapefruit juice-drug interaction issues.
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