Grapefruit juice–nifedipine interaction: possible involvement of several mechanisms

@article{Odou2005GrapefruitJI,
  title={Grapefruit juice–nifedipine interaction: possible involvement of several mechanisms},
  author={P. Odou and N. Ferrari and C. Barth{\'e}l{\'e}my and S. Brique and M. Lhermitte and A. Vincent and C. Libersa and H. Robert},
  journal={Journal of Clinical Pharmacy and Therapeutics},
  year={2005},
  volume={30}
}
Objective:  To develop a model based on mean residence time for better understanding the effect of grapefruit juice on the metabolism of nifedipine (NIF). 
Grapefruit-Drug Interactions
TLDR
The aim of this review is to outline the mechanisms of grapefruit-drug interactions and present a comprehensive summary of those agents affected and whether they are likely to be of clinical relevance. Expand
The effect of grapefruit juice on drug disposition
TLDR
In vitro effects of GFJ and its constituents on the activity of CYP enzymes, organic anion-transporting polypeptides, P-glycoprotein, esterases and sulfotransferases are reviewed. Expand
The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives
TLDR
It has recently emerged that grapefruit, by virtue of its rich flavonoid content, is beneficial in the management of degenerative diseases such as diabetes and cardiovascular disorders. Expand
The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives
  • P. Owira
  • Medicine
  • Cardiovascular Journal of Africa
  • 2012
TLDR
It has recently emerged that grapefruit, by virtue of its rich flavonoid content, is beneficial in the management of degenerative diseases such as diabetes and cardiovascular disorders. Expand
In vitro dissolution of sustained-release Nifedipine brands marketed in the Kumasi Metropolis
A thesis submitted to the School of Graduate Studies in partial fulfilment of the requirement for the Master of Philosophy, 2013
Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models
TLDR
To determine how closely physiologically based pharmacokinetic models can predict oral bioavailability using a priori knowledge of drug‐specific properties, and to examine the influence of the biopharmaceutics classification system class on the simulation success. Expand
Utilizing in vitro and PBPK tools to link ADME characteristics to plasma profiles: case example nifedipine immediate release formulation.
TLDR
Physiologically based pharmacokinetic (PBPK) modeling was used to simulate pharmacokinetics of a nifedipine immediate release formulation following concomitant grapefruit juice ingestion, and a link between the dissolution characteristics of the formulation and its in vivo performance could be established. Expand
Assessment of a Candidate Marker Constituent Predictive of a Dietary Substance–Drug Interaction: Case Study with Grapefruit Juice and CYP3A4 Drug Substrates
TLDR
Results suggest that DHB could be used to predict the CYP3A4-mediated effect of GFJ, and this time- and cost-effective IVIVE approach could be applied to other dietary substance–drug interactions to help prioritize new and existing drugs for more advanced (dynamic) modeling and simulation and clinical assessment. Expand
Grapefruit juice and licorice increase cortisol availability in patients with Addison's disease.
TLDR
Licorice and in particular GFJ increased cortisol available to tissues in the hours following oral CA administration, and both patients and physicians should be aware of these interactions. Expand
Spectroscopic investigation on the food components-drug interaction: the influence of flavonoids on the affinity of nifedipine to human serum albumin.
  • Xuzhe Wang, Yuan-An Liu, +7 authors Xuzhe Wang
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2015
TLDR
Investigation of the interaction between human serum albumin (HSA) and NDP and the influence of flavonoids, rutin and baicalin, on their binding properties were investigated in vitro by means of fluorescence and absorption spectroscopy to show that both hydrogen bonds and hydrophobic interactions play the main role in the binding process. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 29 REFERENCES
Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice.
TLDR
Oral doses of quercetin, similar to those possible from the ingestion of other fruits such as strawberries, do not produce in vivo inhibition of CYP3A mediated metabolism of nifedipine. Expand
Interaction of citrus juices with felodipine and nifedipine
TLDR
Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice; the bioavailability with grapefruit Juice was lower, diastolic blood pressure lower, and heart rate higher with Grapefruit juice than with water. Expand
Influence of grapefruit juice on the pharmacokinetics of a slow release nifedipine formulation.
TLDR
The data contradict the assumption of a selective inhibition of only one cytochrome P450 subfamily and the observed effect could be clinically significant, especially if other factors affecting the elimination of 1 occur. Expand
Grapefruit juice-drug interactions.
TLDR
In vitro findings support the flavonoid, naringin, or the furanocoumarin, 6',7'-dihydroxybergamottin, as being active ingredients, but a recent investigation indicated that neither of these substances made a major contribution to grapefruit juice-drug interactions in humans. Expand
Effects of grapefruit juice on the pharmacokinetics of the calcium channel blockers nifedipine and nisoldipine
TLDR
The observed differences in the effects of GFJ on the pharmacokinetics of nifedipine and nisoldipine appear to be attributable to the differences in their bioavailability, and it would be wise to avoid drinking GFJ within 1 hour before or after taking nis oldipine, because the combination increases plasma drug concentrations. Expand
Factors affecting the absolute bioavailability of nifedipine.
TLDR
The AUC of nifedipine after intravenous administration was significantly higher in South Asian subjects than in Caucasians and this was due to a lower systemic clearance in the South Asians which was 50% of that in the Caucasians. Expand
The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans.
  • Wilkinson
  • Biology, Medicine
  • Advanced drug delivery reviews
  • 1997
TLDR
The extent of this effect appears to be unpredictable, both with respect to a specific drug as well as a particular individual, and the greatest age-related change in oral bioavailability and plasma concentrations is likely to occur with drugs that exhibit a significant first-pass effect in young subjects. Expand
The Nifedipine Gastrointestinal Therapeutic System (GITS)
TLDR
The majority of clinical trials with the nifedipine GITS have assessed its efficacy in patients with mild-to-moderate essential hypertension, and have found it to be at least equivalent to other dosage forms of the drug. Expand
EXTRAHEPATIC FIRST‐PASS METABOLISM OF NIFEDIPINE IN THE RAT
TLDR
Results indicate that, in addition to hepatic extraction, substantial first‐pass elimination of nifedipine occurs within the wall of the small intestine but not the colon of the rat. Expand
...
1
2
3
...