Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats.

@article{Devi2006GrapeSP,
  title={Grape seed proanthocyanidin extract (GSPE) and antioxidant defense in the brain of adult rats.},
  author={A. R. Usha Devi and Adiayara Bosse Jolitha and Naokata Ishii},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2006},
  volume={12 4},
  pages={BR124-9}
}
BACKGROUND Proanthocyanidin (PA) is a naturally occurring antioxidant from grape seed extract. The present study aims at assessing the neuroprotective effects of grape seed proanthocyanidin (GSPE) on the cerebral cortex (CC), cerebellum (CB), and hippocampus (HC) in the adult rat brain. MATERIAL/METHODS GSPE was orally administered at 25, 50, and 75 mg per kg body weight daily and for a total period of 9 weeks. Antioxidant enzymes (AOEs), superoxide dismutase (SOD), and catalase (CAT) were… CONTINUE READING

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