Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism.

@article{Kao2010GrapeSE,
  title={Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism.},
  author={T. Kao and Hung-Chi Tu and Wen-Ni Chang and Bing-Hung Chen and Yanmin Shi and T. Chang and T. Fu},
  journal={International journal of food microbiology},
  year={2010},
  volume={141 1-2},
  pages={
          17-27
        }
}
  • T. Kao, Hung-Chi Tu, +4 authors T. Fu
  • Published 2010
  • Biology, Medicine
  • International journal of food microbiology
Staphylococcus aureus (S. aureus) is one of the most common pathogens that causes infectious and foodborne diseases worldwide. Searching for drug and chemical compounds against this bacterium is still in demand. We found that grape seed extract (GSE), a natural food product rich in polyphenols, inhibited the dihydrofolate reductase activity and growth of S. aureus. In addition, the intracellular content of tetrahydrofolate (THF), the major folate species identified in S. aureus, was… Expand
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