Grape Seed and Skin Extract Protects Against Acute Chemotherapy Toxicity induced by Doxorubicin in Rat Heart

Abstract

Doxorubicin (Dox), an antitumor anthracycline antibiotic, plays a key role in the treatment of many neoplastic diseases. However, its chronic administration induces cardiomyopathy. Increased oxidative stress is a major factor implicated in Dox-induced cardiotoxicity. We hypothesized that a pre-treatment with grape seed and skin extract (GSE), commonly used… (More)
DOI: 10.1007/s12012-012-9155-1

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@article{Mokni2012GrapeSA, title={Grape Seed and Skin Extract Protects Against Acute Chemotherapy Toxicity induced by Doxorubicin in Rat Heart}, author={Meherzia Mokni and Sonia Hamlaoui-Guesmi and Mohamed Amri and Lamjed Marzouki and F{\'e}rid Limam and Ezzedine Aouani}, journal={Cardiovascular Toxicology}, year={2012}, volume={12}, pages={158-165} }