Grape Seed Proanthocyanidin Rescues Rats from Steatosis: A Comparative and Combination Study with Metformin

@inproceedings{Yogalakshmi2013GrapeSP,
  title={Grape Seed Proanthocyanidin Rescues Rats from Steatosis: A Comparative and Combination Study with Metformin},
  author={Baskaran Yogalakshmi and S. Sreeja and Rajagopalan Geetha and Mutlur Krishnamoorthy Radika and Carani Venkataraman Anuradha},
  booktitle={Journal of lipids},
  year={2013}
}
Nonalcoholic fatty liver disease (NAFLD), a premorbid condition, lacks proper management owing to multitude of abnormalities. In this study, we compared the effects of a potent antioxidant, grape seed proanthocyanidins (GSP), and an insulin sensitizer, metformin (MET), in high-fat-fructose-diet- (HFFD-) induced albino Wistar rat model of NAFLD. Either GSP (100 mg/Kg b.w) or MET (50 mg/Kg b.w) or both were administered as therapeutic options. HFFD-fed rats showed abnormal plasma lipid profile… CONTINUE READING
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