Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.

@article{Mllbacher1999GranzymesAT,
  title={Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.},
  author={Arno M{\"u}llbacher and Patrick Waring and R Tha Hla and Thao Tran and Seirei Chin and Thomas Stehl{\'e} and Crisan Museteanu and Markus Michael Simon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 24},
  pages={
          13950-5
        }
}
Analysis of perforin-deficient mice has identified the cytolytic pathway and perforin as the preeminent effector molecule in T cell-mediated control of virus infections. In this paper, we show that mice lacking both granzyme A (gzmA) and granzyme B (gzmB), which are, beside perforin, key constituents of cytolytic vesicles, are as incapable as are perforin-deficient mice of controlling primary infections by the natural mouse pathogen ectromelia, a poxvirus. Death of gzmAxgzmB double knockout… CONTINUE READING
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