Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

@article{Griffiths1993GranzymesAA,
  title={Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor},
  author={Gillian M Griffiths and Sylvie Isaaz},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={120},
  pages={885 - 896}
}
To investigate the question of whether lytic granules share a common biogenesis with lysosomes, cloned cytolytic T cell lines were derived from a patient with I-cell disease. The targeting of two soluble lytic granule components, granzymes A and B, was studied in these cells which lack a functional mannose-6-phosphate (Man-6-P) receptor-mediated pathway to lysosomes. Using antibodies and enzymatic substrates to detect the lytic proteins, I-cells were found to constitutively secrete granzymes A… CONTINUE READING

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