Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

  title={Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor},
  author={Gillian M Griffiths and Sylvie Isaaz},
  journal={The Journal of Cell Biology},
  pages={885 - 896}
To investigate the question of whether lytic granules share a common biogenesis with lysosomes, cloned cytolytic T cell lines were derived from a patient with I-cell disease. The targeting of two soluble lytic granule components, granzymes A and B, was studied in these cells which lack a functional mannose-6-phosphate (Man-6-P) receptor-mediated pathway to lysosomes. Using antibodies and enzymatic substrates to detect the lytic proteins, I-cells were found to constitutively secrete granzymes A… CONTINUE READING


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Hnman and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

  • S. Odake, C. M. Kam, +5 authors J. C. Powers.
  • Biochemistry. 30:2217-2227.
  • 1991
Highly Influential
4 Excerpts

Antibodies as antigens

  • A. Lanzavecchia, S. Abrignani, D. Scheidegger, R. Obrist, B. Dorken, G. Moldanhauer.
  • The use of mouse monoclonal antibodies to focus…
  • 1988
Highly Influential
5 Excerpts

A potyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target ceils

  • H. F. Kern, S. D. Fuller, K. E. Howell
  • 1991

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