Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells

@article{Zhong2012GranzymeKI,
  title={Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells},
  author={Canrong Zhong and Chun Li and X T Wang and Tetsuya Toyoda and Guofen Gao and Zhudi Fan},
  journal={Cell Death and Differentiation},
  year={2012},
  volume={19},
  pages={882-890}
}
The influenza A virus is a causative agent of influenza, which infects human cells and uses host factors to accomplish viral genome replication as part of its life cycle. The nucleoprotein (NP) and PB2 of the influenza virus associate with importin α1 to gain access to the host nucleus through a ternary import complex. Killer cell-mediated cytotoxicity is the primary mechanism of eliminating the influenza virus. Here, we showed that lymphokine-activated killer cells participated in the… CONTINUE READING

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