Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein.

@article{Tang2012GranzymeHO,
  title={Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein.},
  author={Haidong Tang and Chong Li and Li Wang and Honglian Zhang and Zusen Fan},
  journal={Journal of immunology},
  year={2012},
  volume={188 2},
  pages={
          824-31
        }
}
  • Haidong Tang, Chong Li, +2 authors Zusen Fan
  • Published in Journal of immunology 2012
  • Biology, Medicine
  • The granule exocytosis pathway of cytotoxic lymphocytes plays critical roles in eradication of intracellular viruses. However, how hepatitis B virus (HBV) is cleared has not been defined. To clarify immune mechanisms underlying inhibition of the HBV replication, the relationship between granzyme H (GzmH) and HBV clearance was investigated. In this study, we found that the granule exocytosis pathway can inhibit HBV replication without induction of cytolysis of the infected cells. GzmH is… CONTINUE READING

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