Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation.

@article{Gahring2001GranzymeBP,
  title={Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation.},
  author={Lorise C Gahring and Noel G. Carlson and Erin L Meyer and Scott Warren Rogers},
  journal={Journal of immunology},
  year={2001},
  volume={166 3},
  pages={1433-8}
}
Autoimmune processes are initiated when tolerance to self-proteins fails to be established or maintained and immune cells are stimulated by self-Ags. Although intracellular autoantigens are common, the origin of extracellular autoantigens is poorly defined and possibly more dangerous. In this study, we considered a mechanism for the origin of an extracellular autoantigen from the neuronal glutamate receptor subunit 3 (GluR3) in Rasmussen's encephalitis, a severe form of pediatric epilepsy. We… CONTINUE READING