Granzyme B-induced apoptosis in cancer cells and its regulation (review).

@article{Rousalova2010GranzymeBA,
  title={Granzyme B-induced apoptosis in cancer cells and its regulation (review).},
  author={Ilona Rousalova and Ev{\vz}en Křepela},
  journal={International journal of oncology},
  year={2010},
  volume={37 6},
  pages={1361-78}
}
The granzyme B-induced cell death has been traditionally viewed as a primary mechanism that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate harmful target cells including allogeneic, virally infected and tumour cells. Granzyme B (GrB) is the most abundant serine protease which is stored in secretory granules of CTLs and NK cells. After recognition of the target cell, the engaged CTLs and NK cells vectorially secrete GrB along with other granule proteins… CONTINUE READING
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