Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.

@article{Andrade1998GranzymeBD,
  title={Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.},
  author={Felipe Andrade and Sashwati Roy and Donald W. Nicholson and Nancy A. Thornberry and Antony Rosen and Livia A. Casciola-Rosen},
  journal={Immunity},
  year={1998},
  volume={8 4},
  pages={451-60}
}
Caspase-mediated proteolysis of downstream substrates is a critical element of the execution pathway common to all forms of apoptosis studied to date. While this caspase-dependent pathway is activated during cytotoxic lymphocyte granule-induced cell death, recent studies have also provided evidence for caspase-independent pathways. However, the mechanisms mediating these additional pathways have not been defined. The current study demonstrates that DNA-PKcs and NuMA are directly and efficiently… CONTINUE READING

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