Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

@article{Thomas2001GranzymeBC,
  title={Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.},
  author={Dori A. Thomas and Luca Scorrano and Girish V. Putcha and S Stanley J. Korsmeyer and Timothy J. Ley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 26},
  pages={14985-90}
}
Granzyme B (GzmB) is a serine protease that is used by activated cytotoxic T lymphocytes to induce target cell apoptosis. Although GzmB directly cleaves the Bcl2 family member BID on target cell entry, Bid-deficient (and Bax, Bak doubly deficient) cells are susceptible to GzmB-induced death, even though they fail to release cytochrome c from mitochondria. GzmB still induces mitochondrial depolarization in Bax, Bak double knockout cells without cytochrome c release or opening of the permeability… CONTINUE READING

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