Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.


This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with… (More)
DOI: 10.1016/j.vaccine.2009.01.136