Granulomatous amoebic encephalitis: ghost response of an immunocompromised host?

@article{Baig2014GranulomatousAE,
  title={Granulomatous amoebic encephalitis: ghost response of an immunocompromised host?},
  author={Abdul Mannan Baig},
  journal={Journal of medical microbiology},
  year={2014},
  volume={63 Pt 12},
  pages={
          1763-6
        }
}
  • A. Baig
  • Published 1 December 2014
  • Biology, Medicine
  • Journal of medical microbiology
Naegleria fowleri, Acanthamoeba and Balamuthia mandrillaris spp. are known to cause fatal amoebic encephalitis. Here, I attempt to draw attention to these cases, which are reported as ‘granulomatous amoebic encephalitis’ (GAE), and their occurrence in immunocompromised individuals and patients with AIDS. GAE, like any other granulomatous inflammation, can occur only in the presence of ample numbers of CD4 Tlymphocytes. Extensive reviews of manuscripts published over a period of 50 years on this… 
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TLDR
The case of a 27-year-old man with AIDS who presented to a hospital in Atlanta with tonic-clonic seizures and headache is presented as a reminder to the clinician to consider protozoal infections, especially free-living amoeba, in the immunocompromised host with a CNS infection refractory to traditional antimicrobial therapy.
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    Acta tropica
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It is established that with N. fowleri, Acanthamoeba and Balamuthia spp.
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A 74-year-old woman who exhibited drowsiness was referred to a hospital and gradually progressed to a comatose condition with notable brain deterioration of unknown cause, although brain herniation was suspected on follow-up MRI.
A proposed cascade of vascular events leading to granulomatous amoebic encephalitis.
TLDR
This work proposes pathogenetic mechanisms that explain the significant latent period of several months before the appearance of clinical manifestations of Granulomatous amoebic encephalitis due to Acanthamoeba.
Definition of Opportunistic Infections in Immunocompromised Children on the Basis of Etiologies and Clinical Features: A Summary for Practical Purposes
TLDR
The aim of the present review is to provide a comprehensive and ‘easy to read’ text that briefly summarises the currently available knowledge about OIs in order to define when an infection should be considered as opportunistic in pediatrics as a result of an underlying congenital or acquired immune-deficit.
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TLDR
It is shown that under oxidative stress, the defense reactions of the parasite are in part mediated by increasing its antioxidant activity, which is important for the survival of the parasites.
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease
Among various genera of free-living amoebae prevalent in nature, some members are identified as causative agents of human encephalitis, in which Naegleria fowleri followed by Acanthamoeba spp. and…
CPR-Content 15-4
  • 2019

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