Granulocytosis and colony-stimulating activity (CSA) produced by a human squamous cell carcinoma.

@article{Sato1979GranulocytosisAC,
  title={Granulocytosis and colony-stimulating activity (CSA) produced by a human squamous cell carcinoma.},
  author={Noriyuki Sato and Shinichiro Asano and Y. Ueyama and Masaki Mori and Tetsuro Okabe and Yutaka Kondo and Nakaaki Ohsawa and Kinshi Kosaka},
  journal={Cancer},
  year={1979},
  volume={43 2},
  pages={
          605-10
        }
}
A patient with a squamous cell carcinoma accompanied by a marked granulocytosis (100,000/mm3) of unknown origin was examined for Colony-Stimulating Activity (CSA). The pleural fluid and the tumor extract revealed high CSA. The floating cells in the pleural fluid were successfully transplanted into nude mice as a localized tumor with cyst formation. The tumor invariably caused a marked granulocytosis (100,000--300,000/mm3) with induction of a conspicuous splenic granulopoiesis in the… CONTINUE READING
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