Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype.

@article{Kstlin2016GranulocyticMS,
  title={Granulocytic Myeloid-Derived Suppressor Cells Accumulate in Human Placenta and Polarize toward a Th2 Phenotype.},
  author={Natascha K{\"o}stlin and Kathrin Hofst{\"a}dter and Anna-Lena Ostermeir and Baerbel Spring and Anja Leiber and Susanne Haen and Harald Abele and Peter Bauer and J{\"u}rgen Pollheimer and Dominik Hartl and Christian F. Poets and Christian Gille},
  journal={Journal of immunology},
  year={2016},
  volume={196 3},
  pages={1132-45}
}
Tolerance induction toward the semiallogeneic fetus is crucial to enable a successful pregnancy; its failure is associated with abortion or preterm delivery. Skewing T cell differentiation toward a Th2-dominated phenotype seems to be pivotal in maternal immune adaption, yet underlying mechanisms are incompletely understood. Myeloid-derived suppressor cells (MDSCs) are innate immune cells that mediate T cell suppression and are increased in cord blood of healthy newborns and in peripheral blood… CONTINUE READING
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Myeloid derived suppressor cells in human diseases.

International immunopharmacology • 2011
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