Granulocyte transfusions in children and young adults: does the dose matter?

  title={Granulocyte transfusions in children and young adults: does the dose matter?},
  author={Markus G Seidel and Milen Minkov and Volker Witt and Susanne Matthes-Martin and Ulrike Poetschger and Nina Worel and Gerda Leitner and Jan Star{\'y} and Helmut Gadner and C Peters},
  journal={Journal of pediatric hematology/oncology},
  volume={31 3},
BACKGROUND Granulocyte transfusions (GTs) may increase the absolute neutrophil count (ANC) before hematopoietic regeneration in neutropenic patients after chemotherapy or hematopoietic stem cell transplantation and support anti-infective immunity. PROCEDURE We assessed efficacy and tolerability of 778 GTs in 70 treatment episodes of 49 children and 10 young adults [median age 6.28 y (range: 0.13 to 17.7 y) and 21 y (18.0 to 28.0), respectively] suffering from bacterial (n=55) and/or fungal (n… CONTINUE READING


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