Granulocyte-macrophage colony-stimulating factor drives monocytes to CD14low CD83+ DCSIGN- interleukin-10-producing myeloid cells with differential effects on T-cell subsets.

@article{Ganguly2007GranulocytemacrophageCF,
  title={Granulocyte-macrophage colony-stimulating factor drives monocytes to CD14low CD83+ DCSIGN- interleukin-10-producing myeloid cells with differential effects on T-cell subsets.},
  author={Dipyaman Ganguly and Kausik Paul and Jayashree Bagchi and Srabanti Rakshit and Labanya Mandal and Gautam Bandyopadhyay and Santu Bandyopadhyay},
  journal={Immunology},
  year={2007},
  volume={121 4},
  pages={499-507}
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has long been found to have growth-promoting effects on multipotent haematopoietic lineages, specifically granulocytes and macrophages. GM-CSF combined with interleukin-4 (IL-4) drives monocytes to become myeloid dendritic cells (mDCs) in vitro. We report that culturing human monocytes with GM-CSF alone generates myeloid cells (GM-Mono) that have lower expression of CD14 than monocytes and that fail to express DC-SIGN. GM-Monos, however… CONTINUE READING

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