Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice.

@article{Bundschuh1997GranulocytemacrophageCF,
  title={Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice.},
  author={Daniela S. Bundschuh and Johannes Barsig and Thomas Hartung and Felix Randow and W D Doecke and H. D. Volk and Albrecht Wendel},
  journal={Journal of immunology},
  year={1997},
  volume={158 6},
  pages={2862-71}
}
The influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IFN-gamma on the restoration of impaired TNF-alpha release in LPS-desensitized mice or their refractory macrophages was investigated. Mice pretreated with GM-CSF or IFN-gamma (50 microg/kg i.v.) and injected with 3 mg/kg LPS i.p. displayed increased plasma TNF-alpha levels compared with LPS controls. IL-10 was marginally up-regulated by GM-CSF but abrogated by IFN-gamma pretreatment. LPS-tolerant mice (30 microg/kg… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.

Proceedings of the National Academy of Sciences of the United States of America • 2010

Similar Papers

Loading similar papers…