Granulocyte-macrophage colony-stimulating factor enhances exudation of neutrophils to sites of inflammatory challenge in vivo.

Abstract

Priming of neutrophil oxidative responses by granulocyte-macrophage colony-stimulating factor (GM-CSF) has been well documented, but its inhibitory effect on chemotaxis has led to concerns that its therapeutic administration may compromise neutrophil emigration to sites of infection and inflammation. We developed a murine model to determine the… (More)

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