Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.

@article{Son2015GranulocyteMC,
  title={Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.},
  author={Bo-Kyung Son and Daigo Sawaki and Shota Tomida and Daishi Fujita and Kenichi Aizawa and Hiroki Aoki and Masahiro Akishita and Ichiro Manabe and Issei Komuro and Scott L. Friedman and Ryozo Nagai and Toru Suzuki},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          6994
        }
}
Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like factor 6 (KLF6)-myeloid-specific conditional deficient mice exhibit this aortic phenotype when subjected to aortic inflammation. Mechanistically, KLF6 downregulates expression and… Expand
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