Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.

@article{Son2015GranulocyteMC,
  title={Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.},
  author={Bo-Kyung Son and Daigo Sawaki and Shota Tomida and Daishi Fujita and Kenichi Aizawa and Hiroki Aoki and Masahiro Akishita and Ichiro Manabe and Issei Komuro and Scott L Friedman and Ryozo Nagai and T. Suzuki},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={6994}
}
Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like factor 6 (KLF6)-myeloid-specific conditional deficient mice exhibit this aortic phenotype when subjected to aortic inflammation. Mechanistically, KLF6 downregulates expression and… CONTINUE READING

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