Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.

@article{Son2015GranulocyteMC,
  title={Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.},
  author={B. Son and D. Sawaki and Shota Tomida and Daishi Fujita and K. Aizawa and H. Aoki and M. Akishita and I. Manabe and I. Komuro and S. Friedman and R. Nagai and T. Suzuki},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          6994
        }
}
  • B. Son, D. Sawaki, +9 authors T. Suzuki
  • Published 2015
  • Medicine, Biology
  • Nature communications
  • Aortic dissection and intramural haematoma comprise an aortopathy involving separation of the aortic wall. Underlying mechanisms of the condition remain unclear. Here we show that granulocyte macrophage colony-stimulating factor (GM-CSF) is a triggering molecule for this condition. Transcription factor Krüppel-like factor 6 (KLF6)-myeloid-specific conditional deficient mice exhibit this aortic phenotype when subjected to aortic inflammation. Mechanistically, KLF6 downregulates expression and… CONTINUE READING
    GM-CSF: From Growth Factor to Central Mediator of Tissue Inflammation.
    139

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