Granulocyte-macrophage colony-stimulating factor gene-transduced tumor cells combined with tumor-derived gp96 inhibit tumor growth in mice.

@article{Kojima2003GranulocytemacrophageCF,
  title={Granulocyte-macrophage colony-stimulating factor gene-transduced tumor cells combined with tumor-derived gp96 inhibit tumor growth in mice.},
  author={Tetsuya Kojima and Koichi Yamazaki and Yasuaki Tamura and Shigeaki Ogura and Kenzaburo Tani and Jun Konishi and Naofumi Shinagawa and Ichiro Kinoshita and Nobuyuki Hizawa and Etsuro Yamaguchi and Hirotoshi Dosaka-Akita and Masaharu Nishimura},
  journal={Human gene therapy},
  year={2003},
  volume={14 8},
  pages={715-28}
}
Granulocyte-macrophage colony-stimulating factor (GM-CSF)-based cancer cell vaccines have been shown to be potent inducers of antitumor immunity in several murine models, but the antitumor effects on established tumors have been minimal. Conversely, the major role of the heat shock protein gp96, localized in the endoplasmic reticulum (ER), is to act as a molecular chaperone to assist the folding of nascent polypeptide chains in the ER. gp96 derived from tumor cells elicits specific protective… CONTINUE READING

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