Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice.

@article{Campbell1997GranulocytemacrophageCS,
  title={Granulocyte-macrophage colony stimulating factor exacerbates collagen induced arthritis in mice.},
  author={Iain Campbell and Alison M. Bendele and David Smith and John A Hamilton},
  journal={Annals of the rheumatic diseases},
  year={1997},
  volume={56 6},
  pages={364-8}
}
OBJECTIVE To examine the effect of granulocyte-macrophage colony stimulating factor (GM-CSF) on disease progression in the collagen induced arthritis (CIA) model in mice. METHODS DBA/1 mice were primed for a suboptimal CIA response by intradermal injection of chick type II collagen without a secondary immunisation. Three weeks after immunisation the mice were given four to five consecutive daily intraperitoneal injections of recombinant murine GM-CSF (15 micrograms; 5 x 10(5) U), or vehicle… CONTINUE READING
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