Granulocyte-macrophage colony-stimulating factor regulation in murine T cells and its relation to cyclosporin A.

@article{Bickel1988GranulocytemacrophageCF,
  title={Granulocyte-macrophage colony-stimulating factor regulation in murine T cells and its relation to cyclosporin A.},
  author={Matthias Bickel and Sharon M. Wahl and Stephan E. Mergenhagen and Dov H. Pluznik},
  journal={Experimental hematology},
  year={1988},
  volume={16 8},
  pages={691-5}
}
The coordinated expression of the hematopoietic growth factors, interleukin 3 (IL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in activated T cells suggests common synthetic pathways. However, cyclosporin A (CsA) appears to differentially effect the synthesis of these two lymphokines. When the supernatants from the concanavalin A-stimulated thymoma EL-4 or the T-cell hybrid 2B4 were assayed on the GM-CSF/IL3-dependent PT-18 and on the IL3-dependent DA-1 cell lines, IL3… CONTINUE READING