Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial

@article{Carr2009GranulocytemacrophageCS,
  title={Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial},
  author={Robert Carr and Peter Brocklehurst and Caroline J. Dor{\'e} and Neena Modi},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={226-233}
}
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122 Citations
Highly Influential Citations
1
Background Citations
15
Methods Citations
5
Results Citations
2

122 Citations

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Citation Type

Recombinant human granulocyte colony-stimulating factor in preterm neonates with sepsis and relative neutropenia: a randomized, single-blind, non-placebo-controlled trial.
TLDR
Preterm neonates with sepsis and neutropenia treated with rhG-CSF adjunctive therapy have decreased all-cause mortality at discharge and a quicker recovery of their total leucocyte and ANC.
Granulocyte Colony-stimulating Factor for Preterms with Sepsis and Neutropenia: A Randomized Controlled Trial
TLDR
The administration of GCSF in preterms with septicemia and neutropenia resulted in lower mortality rates and duration of NICU stay, and hematological parameters were compared between the two groups.
A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: outcomes at 2 years
TLDR
The administration of GM-CSF to very preterm SGA babies is not associated with improved or more adverse outcomes at 2 years of age, and the apparent excess of developmental impairment in the entire PROGRAMS cohort may represent diffuse brain injury attributable to intrauterine growth restriction.
A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis: childhood outcomes at 5 years
TLDR
The administration of GM-CSF to very preterm SGA babies is not associated with improved or more adverse neurodevelopmental, general health or educational outcomes at 5 years.
University of Birmingham A randomised trial of granulocyte-macrophage colony-stimulating factor for neonatal sepsis
TLDR
GM-CSF was associated with improved neonatal neutrophil counts, but no change in other neonatal or 2-year outcomes, and performance on Kaufmann-ABC subscales and components of NEPSY were similar.
In Vivo Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Neutrophilic Expression of CD11b in Septic Neonates: A Randomized Controlled Trial
TLDR
G-CSF administration as an adjuvant therapy for neonatal septicemia, whether neutropenic or not, improves neutrophilic count and function and contributed to early healing from sepsis.
Effectiveness of Granulocyte Colony‐Stimulating Factor in Hospitalized Infants with Neutropenia
TLDR
G‐CSF treatment decreased the time to hematologic recovery but was associated with increased odds of secondary sepsis and mortality in neutropenic infants, and G‐ CSF should not routinely be used for infants with neutropenia.
Role of G-CSF GM-CSF in the management of infections in preterm newborns: an update.
Late-onset sepsis in preterm infants: update on strategies for therapy and prevention
TLDR
Promising strategies to prevent late-onset sepsis include oral lactoferrin, and pathogen-specific monoclonal antibodies but more evidence is required to make practice recommendations.
Neonatal neutropenia: what diagnostic evaluation is needed and when is treatment recommended?
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References

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The neutrophil count in the rG- CSF-treated group increased significantly faster than that in the placebo or rhuGM-CSF group, and Mortality and neonatal intensive care unit morbidity was not significantly different between the groups.
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TLDR
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TLDR
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TLDR
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TLDR
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