Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways.

@article{Klein2000GranulocytemacrophageCF,
  title={Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways.},
  author={Jon B. Klein and Madhavi J. Rane and Janice A. Scherzer and Patricia Y. Coxon and Ralph Kettritz and Jeanine M. Mathiesen and Abdul Buridi and Kenneth R Mcleish},
  journal={Journal of immunology},
  year={2000},
  volume={164 8},
  pages={
          4286-91
        }
}
Activated neutrophils play an important role in the pathogenesis of sepsis, glomerulonephritis, acute renal failure, and other inflammatory processes. The resolution of neutrophil-induced inflammation relies, in large part, on removal of apoptotic neutrophils. Neutrophils are constitutively committed to apoptosis, but inflammatory mediators, such as GM-CSF, slow neutrophil apoptosis by incompletely understood mechanisms. We addressed the hypothesis that GM-CSF delays neutrophil apoptosis by… CONTINUE READING
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