Granulocyte independence of pulmonary oxygen toxicity in the rat.

  title={Granulocyte independence of pulmonary oxygen toxicity in the rat.},
  author={Neil W Boyce and David A. Campbell and Stephen Roger Holdsworth},
  journal={Experimental lung research},
  volume={15 3},
The role of neutrophils in the mediation of severe normobaric hyperoxic lung injury has been studied by monitoring the effects of neutrophil depletion on a rat model of pulmonary oxygen toxicity. Pulmonary capillary permeability, assessed using an [125I]albumin lung permeability index (LPI), progressively increased with an increased duration of hyperoxia exposure in normal animals (LPI = 0.43 +/- 0.09 at 24 h; 0.95 +/- 0.17 at 48 h; 1.56 +/- 0.21 at 60 h), despite the absence of any significant… CONTINUE READING