Granulocyte-dependent extracellular cytotoxicity is enhanced by complement C3bi and independent of phagocytosis.

Abstract

We have evaluated phagocytosis, C3-binding and cytotoxicity of human leukocytes simultaneously, using IgM-sensitized C3-fragment-bearing sheep erythrocytes (EAC3b, EAC3bi) as targets. In this method, 51Cr-labelled EAC3b or EAC3bi were added to human peripheral granulocytes anchored by fibronectin onto microtitre plate wells. The degrees of haemolysis… (More)

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@article{Kojima1991GranulocytedependentEC, title={Granulocyte-dependent extracellular cytotoxicity is enhanced by complement C3bi and independent of phagocytosis.}, author={Akihiro Kojima and Kaoru Hazeki and Tsukasa Seya}, journal={Scandinavian journal of immunology}, year={1991}, volume={33 6}, pages={707-12} }