Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy.

@article{SkaznikWikiel2013GranulocyteCF,
  title={Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy.},
  author={Malgorzata E Skaznik-Wikiel and Megan M. McGuire and Meena Sukhwani and Julia Donohue and Tianjiao Chu and Thomas Carl Krivak and Aleksandar Rajkovic and Kyle E. Orwig},
  journal={Fertility and sterility},
  year={2013},
  volume={99 7},
  pages={2045-54.e3}
}
OBJECTIVE To examine gonadal protective properties of granulocyte colony-stimulating factor (G-CSF) alone or in combination with stem cell factor (SCF) in female mice treated with high-dose alkylating chemotherapy. DESIGN Experimental laboratory animal study. SETTING Tertiary care academic hospital and research institute. ANIMAL(S) Six- and 8-week-old C57Bl/6 female mice. INTERVENTION(S) Adult female mice were treated with [1] cyclophosphamide and busulfan (CTx), [2] CTx + G-CSF/SCF, [3… CONTINUE READING

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