Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease.

@article{Powell2005GranulocyteCF,
  title={Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease.},
  author={Tiffany M. Powell and Jonathan D. Paul and J. M. D. Hill and Michael Thompson and Moshe Benjamin and M. Rodrigo and J. Philip McCoy and Elizabeth J. Read and Hanh M. Khuu and Susan F. Leitman and Toren Finkel and Richard O. Cannon},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 2},
  pages={296-301}
}
OBJECTIVE Endothelial progenitor cells (EPCs) that may repair vascular injury are reduced in patients with coronary artery disease (CAD). We reasoned that EPC number and function may be increased by granulocyte colony-stimulating factor (G-CSF) used to mobilize hematopoietic progenitor cells in healthy donors. METHODS AND RESULTS Sixteen CAD patients had reduced CD34(+)/CD133(+) (0.0224+/-0.0063% versus 0.121+/-0.038% mononuclear cells [MNCs], P<0.01) and CD133(+)/VEGFR-2(+) cells, consistent… CONTINUE READING
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