Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure.

@article{Garg2012GranulocyteCF,
  title={Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure.},
  author={Vishal Garg and Hitendra Garg and Arshi Khan and Nirupama Trehanpati and Ashish Kumar and Barjesh Chander Sharma and Puja Sakhuja and Shiv Kumar Sarin},
  journal={Gastroenterology},
  year={2012},
  volume={142 3},
  pages={505-512.e1}
}
BACKGROUND & AIMS Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration. METHODS Consecutive patients with ACLF were randomly assigned to groups given 5 μg/kg G-CSF subcutaneously (12 doses; group A, n = 23) or placebo (group B, n = 24) plus standard medical therapy. We assessed survival until day 60; Child… CONTINUE READING
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