Granulocyte colony-stimulating factor: a noninvasive regeneration therapy for treating atherosclerotic peripheral artery disease.

@article{Arai2006GranulocyteCF,
  title={Granulocyte colony-stimulating factor: a noninvasive regeneration therapy for treating atherosclerotic peripheral artery disease.},
  author={Masazumi Arai and Yu Misao and Hiroshi Nagai and Masanori Kawasaki and Kenshi Nagashima and Koji Suzuki and Kunihiko Tsuchiya and Setsuko Otsuka and Yoshihiro Uno and Genzou Takemura and Kazuhiko Nishigaki and Shinya Minatoguchi and Hisayoshi Fujiwara},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2006},
  volume={70 9},
  pages={
          1093-8
        }
}
BACKGROUND The purpose of this study was to determine whether treatment with granulocyte colony-stimulating factor (G-CSF), which mobilizes endothelial progenitor cells from bone marrow, can safely improve the clinical outcomes of patients with atherosclerotic peripheral artery disease (PAD). METHODS AND RESULTS Thirty-nine patients with intractable PAD were randomly assigned to 3 groups: a negative control group (n=12) treated with conventional drug therapy; a positive control group (n=13… CONTINUE READING

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