Granulocyte Macrophage Colony-stimulating Factor : A New Putative Therapeutic Target in Multiple Sclerosis

@inproceedings{McQualter2001GranulocyteMC,
  title={Granulocyte Macrophage Colony-stimulating Factor : A New Putative Therapeutic Target in Multiple Sclerosis},
  author={Jonathan L. McQualter and Rima Darwiche and Christine M Ewing and Manabu Onuki and Thomas W. H. Kay and John A Hamilton and Hugh H Reid and Claude C. A. Bernard},
  year={2001}
}
Experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis, can be induced by immunization with a number of myelin antigens. In particular, myelin oligodendrocyte glycoprotein, a central nervous system (CNS)-specific antigen expressed on the myelin surface, is able to induce a paralytic MS-like disease with extensive CNS inflammation and demyelination in several strains of animals. Although not well understood, the egress of immune cells into the CNS in EAE is governed by a… CONTINUE READING
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