Granulocyte–macrophage colony-stimulating factor: not just another haematopoietic growth factor

@article{FranciscoCruz2013GranulocytemacrophageCF,
  title={Granulocyte–macrophage colony-stimulating factor: not just another haematopoietic growth factor},
  author={Alejandro Francisco-Cruz and M. Aguilar-Santelises and Octavio Ramos-Espinosa and Dulce A Mata-Espinosa and Brenda Marquina-Castillo and Jorge Barrios-Pay{\'a}n and Rogelio Hern{\'a}ndez-Pando},
  journal={Medical Oncology},
  year={2013},
  volume={31},
  pages={1-14}
}
Abstract Granulocyte–macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF has additional effects that may be far more relevant than its haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of macrophages and dendritic cells which are necessary for the subsequent T helper cell type 1 and cytotoxic T lymphocyte activation. GM-CSF… Expand
Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.
  • P. Bhattacharya, I. Budnick, +5 authors B. Prabhakar
  • Biology, Medicine
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  • 2015
TLDR
The pro-inflammatory and regulatory effects of GM-CSF appear to depend on the dose and the presence of other relevant cytokines in the context of an immune response, which will facilitate more appropriate use and thus enhance its clinical utility. Expand
Cytokines, granulocyte-monocyte colony stimulating factor, interleukin-3 and erythropoietin: Can be a therapeutic option for the stimulation of hematopoietic progenitor cells in trauma-hemorrhagic shock?
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TLDR
The present study has shown that HS-induced inflammation leads to drastic changes in active cytokine milieu, which causes multi-organ failure (MOF) and death in human and animal models. Expand
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Keratinocyte Growth Factor Administration Attenuates Murine Pulmonary Mycobacterium tuberculosis Infection through Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF)-dependent Macrophage Activation and Phagolysosome Fusion*
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