Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

@article{Pamir2015GranulocyteMacrophageCF,
  title={Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.},
  author={Nathalie Pamir and N Liu and Angela D. Irwin and Lev Becker and YuFeng Peng and Graziella Eliza Ronsein and Karin E Bornfeldt and Jeremy S. Duffield and Jay W. Heinecke},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 23},
  pages={14656-67}
}
The physiological roles of macrophages and dendritic cells (DCs) in lean white adipose tissue homeostasis have received little attention. Because DCs are generated from bone marrow progenitors in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF), we used GM-CSF-deficient (Csf2(-/-)) mice fed a low fat diet to test the hypothesis that adipose tissue DCs regulate the development of adipose tissue. At 4 weeks of age, Csf2(-/-) mice had 75% fewer CD45(+)Cd11b(+)Cd11c(+)MHCII… CONTINUE READING