Granule size distribution of tablets.

@article{Virtanen2010GranuleSD,
  title={Granule size distribution of tablets.},
  author={Satu Virtanen and Osmo Antikainen and Heikki R{\"a}ikk{\"o}nen and Jouko K Yliruusi},
  journal={Journal of pharmaceutical sciences},
  year={2010},
  volume={99 4},
  pages={2061-9}
}
The purpose of this study was to determine the variation in the granule size distribution in a die of an eccentric tableting machine. Theophylline anhydrate and alpha-lactose monohydrate were granulated with an aqueous solution of polyvinylpyrrolidone, using an instrumented fluid bed granulator. The granules were tabletted, using an instrumented eccentric tableting machine. Punch forces were recorded and tablets were collected in order during the tableting process. Powder samples, which had the… CONTINUE READING
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