Granule neuron regulation of Purkinje cell development: striking a balance between neurotrophin and glutamate signaling.

@article{Morrison1998GranuleNR,
  title={Granule neuron regulation of Purkinje cell development: striking a balance between neurotrophin and glutamate signaling.},
  author={Mark E Morrison and Carol Ann Mason},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 10},
  pages={3563-73}
}
Granule neurons, presynaptic afferents of Purkinje cells, are potent regulators of Purkinje cell development. Purified Purkinje cells survive and differentiate poorly, whereas coculture with granule neurons enhances their survival and dendritic development. Here we investigate the role of neurotrophins in granule-Purkinje cell interactions. BDNF or NT-4 improves, but NT-3 or CNTF reduces, survival of isolated Purkinje cells. When granule neurons are present, however, BDNF or NT-4 treatment… CONTINUE READING
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