Granule deformation and densification during compression of binary mixtures of granules.

@article{Tunn2001GranuleDA,
  title={Granule deformation and densification during compression of binary mixtures of granules.},
  author={Asa Tun{\'o}n and G{\"o}ran Alderborn},
  journal={International journal of pharmaceutics},
  year={2001},
  volume={222 1},
  pages={65-76}
}
The purpose of this study was to investigate whether the deformation and densification during compression of one type of granules are affected by adjacent granules of a different porosity, corresponding to different mechanical strength. Three mixtures were prepared, each consisting of two types of microcrystalline cellulose pellets (intermediate porosity study pellets plus low, intermediate or high porosity surrounding pellets) in the proportion 1:7. The mixtures were compressed and the study… CONTINUE READING

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