Granule cell dispersion in temporal lobe epilepsy is associated with changes in dendritic orientation and spine distribution

@article{Freiman2011GranuleCD,
  title={Granule cell dispersion in temporal lobe epilepsy is associated with changes in dendritic orientation and spine distribution},
  author={Thomas M. Freiman and Jessica Eismann-Schweimler and Michael Frotscher},
  journal={Experimental Neurology},
  year={2011},
  volume={229},
  pages={332-338}
}
Granule cell dispersion is a characteristic feature of Ammon's horn sclerosis in temporal lobe epilepsy. It was recently shown that granule cell dispersion is associated with decreased expression of the extracellular matrix protein Reelin. Reelin controls neuronal lamination and the differentiation of dendrites and spines. Here, we studied dendritic orientation and the distribution of dendritic spines on granule cells in surgical specimens of patients suffering from temporal lobe epilepsy. In… Expand
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